High Purity Protein Production
Xtal will design and produce the protein to best meet your needs with purity >95%. We can develop purification protocols to produce proteins from natural products or tissue/fluid extracts and manufacture challenging proteins and higher order complexes, such as the nucleosome core particle and histone octamers.
Construct Design and Expression System
are determined by how the protein will be used, HTS or assay development. Does it need to be glycosylated or require a tag – cleavable or not? Are there literature precedents?
In addition to purifying recombinant proteins to better than 95% purity using all common types of chromatography, Xtal has successfully purified proteins isolated from shellfish, milk and tissues at scale.
Includes molecular weight, aggregation, purity and a thermal shift trace, which is similar to a fingerprint for the protein. Further thermal shift assays can map the stability of the protein as a function of pH, salt concentration and counter ion.
Xtal has close to 150 high quality, high purity proteins for pilot studies, assay development, HTS, and X-ray crystallography uses. Click here to download our list.