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XTAL BioStructures, Inc
A Collaborative Research Organization
High Quality Protein Production for pilot studies, assay development, HTS, and X-ray crystallography uses.
- Production through E. coli, baculovirus, yeast, or mammalian expression systems.
- XTAL proteins are characterized using SDS-PAGE, mass spectrometry, size-exclusion chromatography, and thermal stability methods.
- Handle challenging proteins or those that require assembly into higher order complexes.
- Scale capacity from mg to gram levels.
- Experience with >125 proteins.
Biophysical Characterization for the measurement of ligand:protein interactions using:
- Thermal Stability Shift (TSS)- may be used to confirm ligand binding, fragment-based screening, or to optimize buffer composition for solubility and stability.
- Isothermal Titration Calorimetry (ITC) for equilibrium binding constants and enthalpy measurements.
- Surface Plasmon Resonance (SPR) for kinetic binding constants.
X-ray Crystallography
- Co-crystallization of small-molecules with proteins for mode-of-binding and structure-guided drug design studies.
- Antibody-antigen structure determinations.
- Synchrotron data collection for highest resolution.
- Novel structure determinations.
Assay Development
- Establish in vitro enzyme, ligand binding, or activation assays.
- Implement cell based assays.
- Mechanism of action evaluations.
Custom Research Projects
- Our versatility and aptitudes provide for a unique environment to perform your research programs that do not fit into standard categories and requirements.
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 OUR FOCUS >
X-Ray Crystallography
Construct Design
Protocol Development
Crystallograpgy Grade
Protein Purification
Crystallization Screening
Co-Crystal Production
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